In this section
Lu AT, GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nature Commun. 2018; 9: 387.
Raj K, The Epigenetic clock and ageing. Epigenetics of Ageing and Longevity. Translational Epigenetics Vol4: 1st Ed. (2017)
Holliman G, Lowe D, Cohen H, Felton S and Raj K. Ultraviolet Radiation-Induced Production of Nitric Oxide:A multi-cell and multi-donor analysis Sci Rep. 2017 Sep 11;7(1):11105. doi: 10.1038/s41598-017-11567-5
Sylwia Kabacik and Ken Raj Ionising radiation increases permeability of endothelium through ADAM10-mediated cleavage of VE-cadherin: Oncotarget 2017 https://doi.org/10.18632/oncotarget.18282
Philipp J, Azimzadeh O, Subramanian V, Merl-Pham J, Lowe D, Hladik D, Erbeldinger N, Ktitareva S, Fournier C, Atkinson MJ, Raj K, Tapio S. Radiation-Induced Endothelial Inflammation Is Transferred via the Secretome to Recipient Cells in a STAT-Mediated Process: J Proteome Res. 2017 Sep 14. doi: 10.1021/acs.jproteome.7b00536.
Azimzadeh O, Subramanian V, Ständer S, Merl-Pham J, Lowe D, Barjaktarovic Z, Moertl S, Raj K, Atkinson MJ, Tapio S. Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways: Int J Radiat Biol. 2017 Sep;93(9):920-928.
Baselet B, Belmans N, Coninx E, Lowe D, Janssen A, Michaux A, Tabury K, Raj K, Quintens R, Benotmane MA, Baatout S, Sonveaux P, Aerts A Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose. Front Pharmacol. 2017 Apr 25;8:213.
Baselet B, Belmans N, Azimzadeh O, Erbeldinger N, Bakshi MV, Dettmering T, Lowe D, Janssen A, Michaux A, , Raj K, , Benotmane MA, Baatout S, Sonveaux P, Aerts, Soile Tapio and Quintens R Differential impact of single-dose Fe ion and X-ray irradiation on endothelial cell transcriptomic and proteomic responses Front Pharmacol. 2017 Sept 25 doi:10.3389/phar2017.00570.
Donna Lowe, Steve Horvath and Kenneth Raj Epigenetic clock analyses of cellular senescence and ageing: Oncotarget (2016) 7(8): 8524-31
The Physiology and Neurobiology group are recognised as international leaders in research and advice regarding the biological and health effects of electromagnetic fields and radiations. They have conducted high quality original research using animal models to explore the consequences of exposure of young, adult or aged animals in order to determine whether exposures to fields commonly encountered in the environment could have unforeseen consequences and be detrimental to health. They have applied this knowledge to give authoritative advice to all stakeholders.
Because of the ubiquity of exposures, including electrical wiring and appliances, and mobile phones, even small risks to the individual could have a substantial health impact for public health. Also each new technological innovation tends to resurrect concerns about cancer, infertility or effects on the brain, and it is essential to maintain a respected source of knowledge and advice.
The Group carries out research specialising in cognitive and behavioural effects, ageing and neurodegeneration, and circadian rhythms and clock gene function, using power frequency magnetic fields and high frequency fields associated with mobile phones. It is also starting to explore the effects of other physical and chemical agents, including diagnostic ultrasound.
The group has close ties with the University of Oxford, plus a number of universities and institutes in the UK and overseas, including the University of Eastern Finland, University of Bordeaux and IS Global in Barcelona.
We are continuously seeking potential collaborations with all research establishments (universities, institutes and government organisations) to study the effects of elctromagnetic fields and other agents on behaviour, the circadian clock and brain function.
Contact us if you would like to find out more detail or stay informed about a particular field of research. We are always interested in collaborating and are open to partnerships, to drive forward innovation for the benefit of the public.